DHCR24 and obesity due to melanocortin 4 receptor deficiency: While the tendency in the global and phosphoproteomics was similar regarding NO production, it was the opposite with atherosclerosis signaling, LXR/RXR activation, DHCR24 signaling and IL-12 signaling, further highlighting the importance of phosphoproteomics in the study of obesity and T2D [84,118,119,120].