While insulin-like growth factor-binding protein complex acid labile subunit (IGFALS), insulin-like growth factor-binding protein 3 (IGFBP3) and insulin-like growth factor 2 (IGF2) revealed a negative correlation with elevated BMI [25], leptin (LEP), fatty acid binding protein 4 (FABP4) and insulin-like growth factor-binding protein 1 (IGFBP1) were positively correlated with increased risk of T2D development [26]. The gene discussed is LEP; the disease is type 2 diabetes mellitus.