Reinforcing STRING and GO analyses summarized in Figure 2, the complement cascade was activated in both pathological conditions, while a considerable difference was observed regarding Liver X Receptor/Retinoid X Receptor (LXR/RXR) activation and Delta(24)-sterol reductase (DHCR24) signaling, with less activity in T2D compared with obesity for both affected canonical pathways. This evidence concerns the gene DHCR24 and type 2 diabetes mellitus.