Reinforcing STRING and GO analyses summarized in Figure 2, the complement cascade was activated in both pathological conditions, while a considerable difference was observed regarding Liver X Receptor/Retinoid X Receptor (LXR/RXR) activation and Delta(24)-sterol reductase (DHCR24) signaling, with less activity in T2D compared with obesity for both affected canonical pathways. The gene discussed is DHCR24; the disease is obesity due to melanocortin 4 receptor deficiency.