While the tendency in the global and phosphoproteomics was similar regarding NO production, it was the opposite with atherosclerosis signaling, LXR/RXR activation, DHCR24 signaling and IL-12 signaling, further highlighting the importance of phosphoproteomics in the study of obesity and T2D [84,118,119,120]. Here, DHCR24 is linked to type 2 diabetes mellitus.