The mechanism of chronic low-grade inflammation in adipose tissue is well investigated; briefly, the aforementioned processes result in the infiltration and transformation of macrophages (M2 to M1) that secrete several kinds of pro-inflammatory cytokines, e.g., interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), known to play a fundamental role in the development of insulin resistance (IR) [66,68]. This evidence concerns the gene TNF and Insulin resistance.