Up-regulated proteins in pT1-HG biopsies are also involved in protein folding (HSP90, HSP70, and HSPA5), oxidative stress (SOD2, HSP90), and immune response (HSP90, HSP70, and HSPA5), three fundamental molecular processes that malignant cells utilize to enable them to thrive under adverse conditions while simultaneously inhibiting the development of anti-tumor immune responses [33]. Here, HSPA5 is linked to neoplasm.