HSPA5 and cancer: On the other hand, the up-regulated proteins in pT1-HG belong to biological processes known to be involved in cancer progression, such as the regulation of nitric oxide (NO) biosynthetic process (KHSRP, SOD2, and HSP90), regulation of signal transduction (S100A9, SOD2, APOA1, HSP90, HSPA5, HINT1, MYDGF, and SerpinB3), and in negative regulation of apoptosis (SOD2, ANXA5, HSP90B1, HSPA5, and MYDGF).