S100A9, which we found up-regulated in pT1-HG biopsies, was identified as a protein associated with iNOS activity [29], and it is also involved in the regulation of signal transduction, such as SOD2, APOA1, HSP90, HSPA5, HINT1, MYDGF, and SerpinB3, and in immunomodulation in tumor microenvironments. This evidence concerns the gene HSPA5 and neoplasm.