HINT1 and neoplasm: S100A9, which we found up-regulated in pT1-HG biopsies, was identified as a protein associated with iNOS activity [29], and it is also involved in the regulation of signal transduction, such as SOD2, APOA1, HSP90, HSPA5, HINT1, MYDGF, and SerpinB3, and in immunomodulation in tumor microenvironments.