In a chronic mild stress (CMS) model of depression characterized by anhedonia, UCP2-deficient mice showed exacerbated depressive behaviors, whereas UCP2 overexpression produced antidepressant effects by suppressing the ROS-thioredoxin-interacting protein (TXNIP)–NLRP3 pathway in astrocytes [23]. The gene discussed is NLRP3; the disease is major depressive disorder.