While the prototypical IDD is multiple sclerosis (MS), those include diseases such as neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), acute disseminated encephalomyelitis (ADEM) and other rarer forms of CNS demyelination. This evidence concerns the gene MOG and neuromyelitis optica.