In the EMIF-AD cohort, Gómez-Pascual et al. integrated lipidomics and proteomics to differentiate normal controls, and MCI and AD patients and to predict MCI-to-AD conversion, with oleamide and proteins such as alpha-synuclein, properdin, PI15 and JPH3 contributing to the high accuracy of the method [32]. The gene discussed is PI15; the disease is Alzheimer disease.