A second study by Zhan et al. integrated AD GWASs with blood and brain eQTLs and mQTLs and showed that mitochondrial genes contribute to risk under the influence of epigenetic and inflammatory regulation, including shared genetic control between mitochondrial loci and cytokines such as LDLR with IL-17C, ACE with IL-18, and PTPMT1 with HGF and OSM [22]. This evidence concerns the gene IL18 and Alzheimer disease.