By employing peripheral blood and tumour specimens from patients with NSCLC, in parallel with in vitro assays using MDSCs and A549 lung adenocarcinoma cells, the authors observed that both chemical (CoCl2) and physiological (1.5% O2) hypoxia strongly induced CD39 and CD73 expression (Figure 1) [11]. Here, ENTPD1 is linked to neoplasm.