TM6SF2 and metabolic dysfunction-associated steatotic liver disease: A minor allele in the human transmembrane 6 superfamily 2 (TM6SF2) gene has been associated with higher fibrosis and NAFLD activity score in children [43], and the involvement of the CB2 Q63R variant of the endocannabinoid system receptor was associated with the severity of inflammation (p = 0.002) and increased predisposition of these patients to develop liver injury [44].