A variant in the glucokinase regulatory protein (GCKR) gene has been associated with an increased rate of DNL in obese adolescents, while other genes such as apolipoprotein C3 (APOC3) or the genes involved in inflammation, oxidative stress and fibrogenesis, such as SOD2, are associated with NAFLD and severity of liver damage [18]. Here, APOC3 is linked to metabolic dysfunction-associated steatotic liver disease.