Risk factors involved in the onset of NAFLD/MASLD in obese children include male gender, positive family medical history, adolescence, Hispanic ethnicity, intestinal dysbiosis, endocrine disorders caused by environmental factors, or the presence of genetic variants of the patatin-like phospholipase domain-containing protein 3 (PNPLA3), membrane-bound acyltransferase 7 (MBOAT7), glucokinase regulatory protein (GCKR), and transmembrane superfamily member 2 (TM6SF2) [11]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.