Thus, the most well-known adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3) gene, a variant in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene, is associated with increased levels of the liver enzymes ALT and AST in young patients, fibrosis development and carcinoma risk, having a higher presence in the Hispanic community. The gene discussed is PNPLA3; the disease is carcinoma.