PSMC6 and type 1 diabetes mellitus: These functional insights may help explain our findings, in which the PSMC6 rs2295825 C allele was associated not only with protection against T1DM but also with a favorable metabolic profile, specifically a 3.58 mg/dL increase in HDL-C and a 16.6% reduction in triglyceride levels, as well as protection against DR (OR = 0.65; p = 0.048).