Thus, as it is known that sOB-R acts to regulate bioavailability of leptin, we suggest future studies to clarify the molecular mechanisms underlying ghrelin’s effects, as well as sOB-R’s effect on obesity (Figure 5), since it was observed that, in hyperleptinemia and hyperghrelinemia, the sOB-R modifies this response. This evidence concerns the gene GHRL and obesity due to melanocortin 4 receptor deficiency.