Consistent with the nature of chronic cholestatic and autoimmune disease, the biochemical signature of PBC includes persistent elevation of alkaline phosphatase (ALP), γ-glutamyltransferase (GGT), and bilirubin serum levels, frequently accompanied by increased immunoglobulin M (IgM) levels [1,20]. The gene discussed is CD40LG; the disease is primary biliary cholangitis.