ALB and primary biliary cholangitis: Specifically, in a large international population of PBC-patients, including a derivation cohort of 11,819 patients and a validation cohort of 1069 patients, ML-based clustering identified four distinct subgroups with unique clinical phenotypes and prognostic trajectories: patients with excellent long-term outcomes (cluster 1); individuals with worse prognosis, differing from cluster 1 primarily by albumin levels near the lower limit of normal (cluster 2); younger patients with pronounced cholestasis (cluster 3); advanced-stage cases with poor prognosis (cluster 4).