Interestingly, mutations in TET2 are somatic (acquired) and commonly found in (1) myeloid malignancies such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML); myeloproliferative neoplasms (MPNs); and (2) lymphoid cancers such as Angioimmunoblastic T-cell lymphoma (AITL) and Peripheral T-cell lymphoma (PTCL). This evidence concerns the gene TET2 and acute myeloid leukemia.