In our Chinese cohort, FLNC nonsense mutations appear to be associated with a distinctive right-heart phenotypic profile—characterized by notable tricuspid regurgitation and diminished pulmonary artery flow velocity—which may extend the conventional understanding of FLNC truncating variants that have traditionally centered on arrhythmia and left ventricular dilation. The gene discussed is FLNC; the disease is Tricuspid regurgitation.