TGFB1 and heart failure: In summary, ADAMTS1 functions as a “signal convergence node” in the pathological progression of heart failure following myocardial infarction, integrating the regulation of three key pathological signals: inflammatory mediators (e.g., IL-17A), neurohormonal pathways (e.g., the aldosterone-mineralocorticoid receptor pathway), and pro-fibrotic factors (e.g., TGF-β, Ang II).