ADAMTS1 and thoracic aortic aneurysm: However, a systematic review of existing literature reveals “contradictory” and “context-dependent” roles for ADAMTS1: for instance, Adamts1 haploinsufficient mice spontaneously develop thoracic aortic aneurysms and dissections (TAAD), indicating its critical importance for vascular homeostasis [14]; yet, in other contexts, ADAMTS1 upregulation correlates with pathological tissue remodeling, driving disease progression by promoting ECM degradation [6,8].