Strong clinical evidence from human studies corroborated this function: compared to patients with stable angina, ADAMTS1 expression is significantly elevated in unstable coronary plaques from acute myocardial infarction patients, with its localization colocalizing with macrophages and the cleavage site of the multifunctional proteoglycan versican [18]. Here, ADAMTS1 is linked to acute myocardial infarction.