Interestingly, the analysis of clonal hierarchy of del(5q) and TP53 mutations showed that the VAF of del(5q) (considered as a measure of cytogenetic del(5q) clone size comparable to VAF of mutations) was similar in both MDS del(5q) and MDS-CK, while the VAF of TP53 mutations was lower in MDS del(5q) than in MDS-CK [10]. The gene discussed is TP53; the disease is myelodysplastic syndrome.