Interestingly, in AML as well, there are two groups of AMLs with del(5q) with distinct biologic features: one group with isolated del(5q), associated with frequent IDH1 or IDH2 mutations and with less frequent TP53 mutations; and a second group with del(5q) observed in the context of CK and characterized by frequent TP53 mutations [26]. This evidence concerns the gene TP53 and acute myeloid leukemia.