Thus, Montoro et al. explored the group of MDS with multihit TP53 alterations with emphasis on the comparison of the prognosis of the subgroup of patients with TP53 biallelic alterations and isolated del(5q) and of the subgroup of patients with biallelic TP53 alterations without isolated del(5q), with low blast cell number [126]. Here, TP53 is linked to myelodysplastic syndrome.