The analysis of clonal architectures of MDS with deletions of 5q showed that not in all cases del(5q) is a primary hit; in fact, in some MDS, del(5q) is preceded by other mutations, such as TP53 mutations; in other MDS, del(5q) is codominant with TP53 mutations [32]. Here, TP53 is linked to myelodysplastic syndrome.