TP53 and myelodysplastic syndrome: A fundamental study by Bernard et al. reported the molecular analysis of 3234 MDS patients, including 3787 TP53-mutated patients: 72.5% with a single mutation, 26.5% with two mutations and 1% with three mutations; allelic imbalance (due to focal deletions or regions of cnLOH) was observed in 178 patients [16].