CSNK1A1 haploinsufficiency in MDS-del(5q) leads to increased platelet counts, while recurrent somatic mutations of CSNK1A1 within the del(5q) CDR in MDS determine a homozygous CSNK1A1 defect with concurrent thrombocytopenia in the affected patients [46]. This evidence concerns the gene CSNK1A1 and myelodysplastic syndrome.