Among these genes, the gene encoding α-catenin (CTNNA1), located at 5q32.1, is expressed at markedly lower levels in leukemia-initiating cells from MDS or AML patients with del(5q) than in AML or MDS patients without del(5q) or in normal HSCs [59]. The gene discussed is CTNNA1; the disease is myelodysplastic syndrome.