A distinctive feature of classical HL is the amplification of the 9p24.1 chromosomal region, leading to overexpression of programmed cell death protein 1 (PD-1) ligands PD-L1 and PD-L2 on RS cells, which promotes immune evasion through the PD-1 pathway [8,9,10,11,12]. Here, PDCD1 is linked to Hodgkins lymphoma.