Interestingly, NGS analysis did not detect any mutations in all the other KIT exons (2, 8–11, 13, 17, 18) analyzed nor in other genes previously reported in patients with advanced systemic mastocytosis (TET2, SRSF2, ASXL1, RUNX1, CBL, JAK2, NRAS, and KRAS). The gene discussed is CBL; the disease is systemic mastocytosis.