IGF1R and cancer: Other than its main endocrine-disrupting effect established through binding to ERs, BPA also binds to several different receptors involved in cancer signaling pathways, including androgen receptor (AR), G protein-coupled estrogen receptor (GPER; G protein-coupled receptor 30, GPR30), insulin-like growth factor-1 receptor (IGF-1R), and estrogen-coupled receptor gamma (ERRc) [16].