In rodent models of PCOS, treatment with 300 mg/kg metformin, 30 mg/kg flutamide, or their combination for six weeks demonstrated differential effects: metformin improved fasting insulin and HOMA-IR, while flutamide and combination therapy reduced plasma triglycerides, ApoB48, and ApoB100 [21]. The gene discussed is INS; the disease is polycystic ovary syndrome.