The principal mechanisms of drug-induced hyperglycemia include diminution of insulin secretion and/or insulin production, diminution of peripheral insulin sensitivity and/or promotion of weight gain, an increase in glucose production through promotion of hepatic gluconeogenesis, and/or glycogenolysis and destruction of pancreatic cells, leading to beta-cell injury [25,184,185,186]. The gene discussed is INS; the disease is Hyperglycemia.