An elegant study from Catherine Muller’s group demonstrated that obesity induces PPAT to secrete CCL7, which, in turn, promotes the directed migration of PCa cells expressing the C-C motif chemokine receptor 3 (CCR3), the CCL7 receptor, thereby facilitating extraprostatic extension and metastasis development [6]. Here, CCL7 is linked to obesity due to melanocortin 4 receptor deficiency.