The autophagy–PANoptosis interaction is particularly relevant in SLE because autophagy impairment amplifies the type I IFN response, increases mitochondrial ROS, and enhances ZBP1 expression—directly lowering the threshold for PANoptotic activation in neutrophils and pDCs [42,143,161,162,163]. The gene discussed is ZBP1; the disease is systemic lupus erythematosus.