TNF and rheumatoid arthritis: Inhibition of the RIPK1–RIPK3 signaling complex, a central element of the PANoptosome, has demonstrated the ability to suppress necroinflammatory signaling and diminish downstream inflammatory cell death in preclinical models, underscoring its therapeutic potential, especially in environments rich in TNF and IL-17, such as RA and psoriasis [31,32].