The largest study, from PETHEMA, identified age over 60 years, male gender and fever at presentation as independent prognostic factors for ED due to infection; an Eastern Cooperative Oncology Group (ECOG) performance status above 1 and low albumin as independent predictors of DS-related ED; and abnormal creatinine, increased peripheral blast counts and coagulopathy as independent prognostic factors for hemorrhage-related ED [6]. Here, ALB is linked to blood coagulation disease.