Because COPD and IPF share features such as chronic hypoxemia, reduced physical activity, systemic inflammation, frailty, and progressive functional decline, it is biologically plausible that senescence-related factors like GDF-15, IL-6, TNF-α, and other inflammatory mediators may similarly influence the “lung–brain–muscle” axis in IPF. The gene discussed is GDF15; the disease is idiopathic pulmonary fibrosis.