AD associated with FLG mutations has a distinct phenotype (AD FLG) characterized by earlier onset and persistent disease, increased severity, predilection to the cheeks and hands, palmar hyperlinearity, increased risk of eczema herpeticum and staphylococcal infection, increased risk of asthma (including treatment-resistant asthma), and increased risk of food allergy as well as allergic sensitization [18]. This evidence concerns the gene FLG and Alzheimer disease.