THBS1 and periodontitis: CD47 is an integrin-associated protein able to suppress phagocytosis, which interacts with other innate immune receptors like TLR2, related to intracellular Porphyromonas gingivalis survival in macrophages depending on the bacterial major fimbria, and causes the increased expression and secretion of the CD47 ligand THBS1 following Porphyromonas gingivalis infection, which protects periodontitis-associated bacterial species from neutrophil bactericidal activity, helping bacteria survive in an inflamed environment and cause dysbiosis [84].