WNK2 and cancer: Max dimerization protein 3 (MXD3) is a transcription factor that plays a crucial role in cell proliferation by regulating gene transcription, and its overexpression has been associated with decreased sensitivity of cancer cell lines to several mitogen-activated protein kinase inhibitors, and increased activities of other kinase inhibitors, including Akt inhibitors, suggesting that it is an immune-oncogenic molecule and could become a biomarker for cancer detection, prognosis, and therapeutic design [149].