In the lectin pathway, lectin-associated serine protease 2 (MASP2) is activated with pattern-recognition molecules like mannose-binding lectin (MBL) and ficolins, which bind to carbohydrate structures, such as the mannose residues often found on the surface of pathogens or aberrantly glycosylated tumor cells [182]. The gene discussed is MASP2; the disease is neoplasm.