GTF2H4 and ischemic disease: General TF IIH Subunit 4 (GTF2H4) is a subunit of the DNA repair and transcription complex TFIIH and has been linked to lung cancer susceptibility, promoting partial endothelial-to-mesenchymal transition and angiogenesis under hypoxic conditions in ischemic diseases, suggesting it may play a role in promoting tumor vascularization and growth [146].