Porphyromonas gingivalis infection is related to periodontitis and can also modulate the WNT signaling pathway, including WNT5A, which increases the activity of the β-catenin-dependent TCF/LEF promoter in epithelial cells (Figure 6), which may contribute to a proliferative phenotype and modulate the inflammatory processes [74]. This evidence concerns the gene WNT5A and periodontitis.