SDC1 regulates epithelial plasticity and coordinates lung fibrosis programs, altering alveolar type II cell phenotypes through the activation of profibrotic pathways like TGF-β and Wnt, controlling the packaging of several antifibrotic miRNAs into EVs that have wide outcomes over those fibrogenic signaling networks [58]. This evidence concerns the gene TGFB1 and pulmonary fibrosis.