Some secreted proteins, such as growth factors, cytokines, or extracellular matrix components (e.g., Bone morphogenetic protein 2 (BMP2), ADAM metallopeptidase with thrombospondin type 1 motif 16 (ADAMTS16), Tenascin-XB (TNXB)) are released to degrade the surrounding matrix for tumor microenvironment remodeling, creating pathways for invasion and metastasis [133]. The gene discussed is ADAMTS16; the disease is neoplasm.