Tumor cells often overexpress glycosyltransferases, particularly the GALNT family, which produces unique and abnormal glycan patterns primarily by initiating or altering O-glycosylation, probably supported by GALNT9-AS1, altering the function of cell surface proteins, altering critical cellular processes like adhesion, signaling, and immune evasion to promote cancer progression by Wnt/β-catenin signaling pathway via abnormal o-glycosylation of CD44 to enhance malignancy [180]. This evidence concerns the gene CD44 and cancer.