Integrin subunit alpha 5 (ITGA5) belongs to the integrin alpha chain family of extracellular matrix receptors, is vital for promoting cancer cell invasion and metastasis, is significantly associated with tumor purity and immune infiltration levels of different immune cells in gastrointestinal tumors [45], and is positively correlated with lymph node metastasis and the TNM stage of GC, shorter overall survival, and disease-free survival [46]. This evidence concerns the gene ITGA5 and gastric cancer.