Search terms included combinations of “inflammasome,” “NLRP3,” “AIM2,” “IFI16,” “dental pulp,” “pulpitis,” “periodontitis,” “chronic oral inflammation,” “interleukin-1β,” “interleukin-18,” “oral squamous cell carcinoma,” “oral cancer,” “NF-κB,” “bacterial pathogens,” and related terms. The gene discussed is IL18; the disease is periodontitis.