For example, miR-19b-3p is highly expressed in renal tubular epithelial cell-derived EVs and has been shown to mediate macrophage activation by targeting nuclear factor-kappa B (NF-κB)/suppressor of cytokine signaling-1 (SOCS-1) in a lipopolysaccharide (LPS)-induced acute kidney injury (AKI) mouse model [7]. This evidence concerns the gene SOCS1 and acute kidney injury.