In addition, pathway enrichment analysis revealed significant involvement of several canonical RA-associated signaling pathways, including Janus kinase-signal transducer and activator of transcription (JAK-STAT), tumor necrosis factor (TNF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and mitogen-activated protein kinase (MAPK) signaling pathways. The gene discussed is TNF; the disease is rheumatoid arthritis.