STAT2 and neoplasm: However, because we previously showed that STAT2 promotes tumor development in a model of colitis-associated cancer [15] and given that IFN-I signaling was established as tumor-suppressive and a predictor of overall survival in colon cancer [35,36,37] with STAT2 inactivation [11], we sought to determine whether STAT2 exhibits a similar or distinct association with patient outcomes.