Azizi et al. (2020) identified several risk factors associated with adverse visual outcomes in pediatric NF1-OPG patients, including multiple visual signs and symptoms at diagnosis (adjusted odds ratio [adjOR]: 8.33; 95% CI: 1.9–36.45), abnormal visual behavior (adjOR: 4.15; 95% CI: 1.20–14.34), new onset of visual symptoms (adjOR: 4.04; 95% CI: 1.26–12.95), and optic atrophy (adjOR: 3.73; 95% CI: 1.13–12.53) [4]. This evidence concerns the gene NF1 and optic atrophy.