MTHFR and androgen insensitivity syndrome: Similarly, Miravet et al. [13] and Ganesan V. [51], in their studies, identified several children with, respectively, heterozygous or homozygous MTHFR mutations and low levels of protein S, protein C, or antithrombin III among a cohort of patients with VZV-related AIS, further supporting the hypothesis that genetic predisposition may modulate disease severity and outcome.