Moreover, comparisons of BMAL1 and SIRT1 levels across four different time subgroups in patients (00:00–05:59, 06:00–11:59, 12:00–17:59, and 18:00–23:59) revealed that expression levels were lowest in patients with ischemic stroke onset at 6:00–11:59. Here, SIRT1 is linked to ischemic stroke.