IL6 and Mental deterioration: Since biomarkers such as systemic inflammation and cellular stress response are associated with cognitive health [62,63,64], and MPIL is associated with lower interleukin-6 (IL-6) plasma levels [65], lower hemoglobin A1c (HbA1c) levels [66], and lower cortisol levels [67], it stands to reason that MPIL would be associated with better cognitive functioning and slower cognitive decline.