Increased expression of E-Cadherin was associated with reduced protein levels of Snail and Slug, transcription factors that are highly expressed in various tissues and cancer types and that are well known to promote the epithelial-to-mesenchymal transition (EMT) and mesenchymal differentiation by inhibiting CDH1 (E-Cadherin) expression [43,44]. The gene discussed is SNAI2; the disease is cancer.