TARDBP and amyotrophic lateral sclerosis: Specifically, these assembly modulators, rescued motor function in C. elegans expressing ALS-linked A315T TDP-43 mutant, reduced lethality in Drosophila expressing (G4C2)30 repeat expansions, and prevented weight loss and neurofilament elevation in superoxide dismutase 1 (SOD1)-G93A mice [28].