HiPSC-derived astrocytes, K3P53 (referred to as WT astrocytes), and astrocytes carrying PSEN-1 A280E, APP London, or APP Swedish mutations (referred to as AD astrocytes) were incubated with [U-13C]glucose in the absence and presence of unlabeled 12C10 (Figure 3). This evidence concerns the gene APP and Alzheimer disease.