CD8+ T-cell priming by B cells may require costimulatory signals from a proinflammatory environment, such as the intense inflammation during streptococcal tonsillopharyngitis, which may be enhanced by psoriasis-associated gene variants affecting regulators of innate host defense [98] and further involve B-cell-related psoriasis susceptibility loci [99] and imbalanced B-cell production of pro- and anti-inflammatory cytokines [24,25,26]. Here, CD8A is linked to psoriasis.