Regardless of this, the HLA-C*06:02-restricted cross-reactivity of the psoriatic Vα3S1/Vβ13S1 TCR against B cells and melanocytes and the auto-stimulatory property of B cells for CD8+ T cells from psoriasis patients support the notion that B cells in secondary lymphoid organs might activate CD8+ T cells, which subsequently mediate the psoriatic autoimmune response against melanocytes in the skin. Here, CD8A is linked to psoriasis.