They suggest that the pro-inflammatory environment of streptococcal tonsillopharyngitis may enable B cells in the tonsils of HLA-C*06:02+ individuals to prime autoreactive CD8+ T cells by various self-peptides from the B-cell immunopeptidome, which subsequently cross-react against melanocytes in the skin and trigger psoriasis. This evidence concerns the gene HLA-C and psoriasis.