Accordingly, the reactivity of Vα3S1/Vβ13S1 TCR, which reveals the antigen specificity of a lesionally expanded psoriatic CD8+ T-cell clone, suggests that a diverse group of self-peptides derived from the B-cell proteome and presented by HLA-C*06:02 may ultimately trigger the autoimmune response of CD8+ T cells against melanocytes in psoriasis. The gene discussed is CD8A; the disease is psoriasis.