The Vα3S1/Vβ13S1 TCR is pathognomic of the psoriatic autoimmune response in that it rearranges the Vβ13S1-variable region gene in the TCR β-chain (Arden nomenclature [95], corresponding to Vβ 6-5 IMGT gene designation), which is preferentially utilized by the clonal CD8+ T cells infiltrating the epidermis of psoriasis lesions [6]. This evidence concerns the gene CD8A and psoriasis.