BDNF and Stroke: Stroke models have provided converging evidence: Gao and colleagues showed that seven days of 20 Hz rTMS increased the Bcl-2/Bax ratio in a rat middle cerebral artery occlusion (MCAO) model [44], while Guo and colleagues reported enhanced BDNF-TrkB signaling and a higher Bcl-2/Bax ratio following 14 days of 10 Hz stimulation [45].