SOX8 and ovarian cancer: In ovarian cancer, a comparison of PDOs from Cisplatin-sensitive and -resistant patients revealed that resistant organoids overexpressed Aurora A. This kinase activated the SOX8-FOXK1 signaling pathway, which in turn regulated genes involved in cell senescence and glycolysis, identifying the Aurora A–SOX8–FOXK1 axis as a key driver of cisplatin resistance [57].