MECP2 and Cerebral ischemia: Sun et al. [109] revealed that under cerebral ischemia, lactylation of MeCP2 at K210 and K249 causes MeCP2 to accumulate at promoters of apoptosis-related genes Pdcd4 and Pla2g6, repressing their transcription and reducing neuronal apoptosis, thereby conferring neuroprotection.