In liver fibrosis, Rho et al. demonstrated that hexokinase 2 (HK2) in activated hepatic stellate cells (HSCs) induces lactate production; histone lactylation, particularly H3K18la, then promotes expression of α-SMA, COL1A1, and TIMP1, advancing liver fibrosis. Here, ACTA1 is linked to Hepatic fibrosis.