ALDOA and congenital bilateral aplasia of vas deferens from CFTR mutation: Wu et al. [100] reported in the context of calcific aortic valve disease (CAVD) that lactate induces lactylation at the K42 site of aldolase A (ALDOA), which promotes the osteogenic differentiation of human aortic valvular interstitial cells (hVICs) and thereby drives the process of valvular calcification.