Xiong et al. further demonstrated that lactate in TME induces H3K18la to upregulate METTL3, whose K281 and K345 sites are lactylated; this enhances METTL3-mediated m6A modification of Jak1 mRNA, activating JAK–STAT3 signaling and promoting expression of immunosuppressive genes such as IL-6, thereby augmenting immunosuppressive functions of tumor-infiltrating myeloid cells [60]. The gene discussed is METTL3; the disease is neoplasm.