NCOA4 and Alzheimer disease: An et al. reported that Tau protein lactylation modulates ferritinophagy in AD: Tau K677 lactylation, through the MAPK pathway, increases expression of ferritinophagy-related proteins NCOA4, ATG5, Beclin1, and LC3II, promoting ferritinophagy and ferroptosis, as well as exacerbating AD progression [69].