Chen et al. [98] showed that METTL7B overexpression in cardiomyocytes and mouse hearts promotes m6A-mediated degradation of USP38 mRNA, reducing HDAC3 expression and thereby diminishing its de-lactylase activity; this increases H3K18la, downregulates β-MHC, ANP and BNP expression, attenuates remodeling, and improves cardiac function, delaying HF. This evidence concerns the gene NPPB and hydrops fetalis.