Li et al. found that lactylation of aldehyde dehydrogenase 2 (ALDH2) disrupts its interaction with the mitophagy receptor prohibitin 2 (PHB2), promoting PHB2 ubiquitination and proteasomal degradation, thereby inhibiting mitophagy and worsening mitochondrial dysfunction in acute kidney injury [70]. The gene discussed is PHB2; the disease is acute kidney injury.