The transcriptional reprogramming of monocytes due to tumor signals (such as IL-6, IL-10, and TGF-β) mainly relies on activation of the signal transducer and activator of transcription 3 (STAT3), leading to the upregulation of genes associated with anti-inflammatory cytokines, pro-angiogenic molecules, and growth factors [67,69]. This evidence concerns the gene IL6 and neoplasm.