CSF2 and neoplasm: Tumors are considered chronic inflammatory areas and sites of tissue remodeling, thus activating the innate immune response by the constant release of inflammatory signals (TNF-α, interleukins such as IL-1β, IL-6) and growth factors (granulocyte-monocyte colony-stimulating factor, GM-CSF, VEGF-A, TGF-β) that shape the tumor microenvironment (TME) and support tumor progression and metastasis [49].