While anti-tumoral effects by supporting CD8+ and CD4+ T cell activation have been observed [47], this subset was found to interfere with NK cell anti-tumor responses by secreting IL-10 and inducing the expression of the immune checkpoint molecule TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domain) in NK cells of colorectal cancer patients [48]. The gene discussed is CD4; the disease is neoplasm.