In addition, FAK phosphorylation and RhoA phosphorylation levels (as evaluated using the pFAK/FAK and pRhoA/RhoA protein ratios) were also significantly reduced in EphA2-knockdown RCC kidneys compared to those in the control RCC kidneys (p = 0.034, p = 0.014, respectively). The gene discussed is EPHA2; the disease is renal cell carcinoma.