TFEB has garnered attention as a modulator of neurodegenerative disease progression: overexpression of TFEB can improve cellular and organismal health in several murine neurodegenerative disease models, including models of Parkinson’s, Huntington’s and Alzheimer’s disease, by inducing autophagy to degrade toxic protein aggregates, and depletion of TFEB can cause accelerated disease progression [87,247,255,256,257]. This evidence concerns the gene TFEB and neurodegenerative disease.