Pathogenic mutations in VCP/p97 cause disorders including frontotemporal dementia, amyotrophic lateral sclerosis, and Parkinsonism; in addition to promoting lysophagy, VCP/p97 is also an effector of macroautophagy, and both of these functions likely contribute to neuron pathologies [284,285]. Here, VCP is linked to amyotrophic lateral sclerosis.