In parallel, increased expression of stress-response and proteostatic regulators (Hspa5, Hspa8, Hsp90ab1) and developmental or state-transition TFs (Sox, Hes, Ccnd family) suggests that RXR activation enhances metabolic support, modulates glial activation programs, and may improve resilience to inflammatory or injury-related stress in AD-like pathology. This evidence concerns the gene HSPA5 and Alzheimer disease.