In CRC models, pyrvinium pamoate has not been reported to impact mitochondrial activity but rather to downregulate STAT3 phosphorylation, a key metabolic and oncogenic transcription factor, and to suppress PI3K/Akt/mTOR signaling, ultimately leading to cell cycle arrest and autophagy-mediated cell death [75]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.