Transcriptomic and proteomic analyses revealed significantly altered levels of transcripts (RN7SL3, RN7SL1, miR19B2, SYF2P2, and S100A7) and proteins (psoriasin [S100A7] and dystroglycan 1) in patients with MSA-P compared with those with Parkinson’s disease. This evidence concerns the gene S100A7 and Parkinson disease.