Beyond this general metabolic alteration, MTAP deficiency leads to enhanced expression of hypoxia-inducible factor 1α (HIF1-α) and activation of RIO kinase 1 (RIOK1) in pancreatic cancers, prompting metabolic adaptation towards a glycolytic phenotype and de novo purine synthesis [58]. The gene discussed is RIOK1; the disease is familial pancreatic carcinoma.