It has also been shown that while the TNFA level is correlated with inflammation-related miRNA expression, such as miR-155 [105], miR-155-5p plays a key role in the pathogenesis of IBD by suppressing the expression of proteins involved in maintaining gut barrier integrity, including CLDN1 and ZO-1 expression, thereby contributing to gut dysbiosis [106]. The gene discussed is TNF; the disease is irritable bowel syndrome.