These results suggest that ERE73 (1 + 2)-ARF (−13) and ERE73 (3 + 4)-ARF (−13) have similar activity to the hTERT, ARF, and E2WT-ARF (−13) promoters in Saos-2 cancer cells, while exhibiting much weaker activity in normally growing cells. The gene discussed is CDKN2A; the disease is cancer.