These results demonstrate that the ERE73 (1 + 2) and ERE73 (3 + 4) elements confer superior cancer cell specificity on the ARF (−13) core promoter, compared to the E2F1, hTERT, and native ARF promoters and E2WT-ARF (−13) construct, in these cancer cell lines. Here, CDKN2A is linked to cancer.