Excessive activation of 5–LOX, 12–LOX, and 15–LOX in HT may lead to increased pro–inflammatory eicosanoids such as 5S–HETE, 12S–HETE, 15S–HETE, and 5–oxo–ETE, which may contribute to thyroid cancer development. The gene discussed is LOX; the disease is thyroid gland carcinoma.