Excessive activation of 5–LOX, 12–LOX, and 15–LOX in HT may lead to increased pro–inflammatory eicosanoids such as 5S–HETE, 12S–HETE, 15S–HETE, and 5–oxo–ETE, which may contribute to thyroid cancer development. This evidence concerns the gene SPRR2A and thyroid gland carcinoma.