In our previousstudy, an irrelevant IgG1-Fc-blocking agent enhanced the tumor accumulationof [89Zr]­Zr-2A10-VH-FcWT and [89Zr]­Zr-m912anti-MSLN antibodies in NCG xenograft. However, the efficacy of utilizing the Fc silencing strategy toimprove the imaging contrast in the clinic remains to be explored,given that most patients will not be as immunocompromised as NCG mice. This evidence concerns the gene MSLN and neoplasm.