In summary, this study demonstrates thatFc-engineering of anti-MSLNVH-Fc fusion proteins, particularly those bearing the LALAPG mutation,provides significant improvements in tumor targeting and biodistribution.Selective modulation of Fc silencing to reduce FcγR interactionsimproved tumor-specific accumulation and provided favorable tumor-to-backgroundcontrast. Here, FCGR2A is linked to neoplasm.