The [89Zr]­Zr-2A10-VH-FcLALAPG mutant, whichdemonstrated higher tumor accumulation and reduced off-target distributionin HCT116 xenografts relative to those of [89Zr]­Zr-2A10-VH-FcWT and [89Zr]­Zr-2A10-VH-FcGRLR, was furtherassessed in additional MSLN-positive xenograft models. Here, MSLN is linked to neoplasm.